RT Journal Article SR Electronic T1 Progress in oncolytic viruses modified with nanomaterials for intravenous application JF Cancer Biology & Medicine JO Cancer Biology & Medicine FD China Anti-Cancer Association SP 20230275 DO 10.20892/j.issn.2095-3941.2023.0275 A1 Chen, Liting A1 Ma, Zhijun A1 Xu, Chen A1 Xie, Youbang A1 Ouyang, Defang A1 Song, Shuhui A1 Zhao, Xiao A1 Liu, Funan YR 2023 UL http://www.cancerbiomed.org/content/early/2023/11/24/j.issn.2095-3941.2023.0275.abstract AB In oncolytic virus (OV) therapy, a critical component of tumor immunotherapy, viruses selectively infect, replicate within, and eventually destroy tumor cells. Simultaneously, this therapy activates immune responses and mobilizes immune cells, thereby eliminating residual or distant cancer cells. However, because of OVs’ high immunogenicity and immune clearance during circulation, their clinical applications are currently limited to intratumoral injections, and their use is severely restricted. In recent years, numerous studies have used nanomaterials to modify OVs to decrease virulence and increase safety for intravenous injection. The most commonly used nanomaterials for modifying OVs are liposomes, polymers, and albumin, because of their biosafety, practicability, and effectiveness. The aim of this review is to summarize progress in the use of these nanomaterials in preclinical experiments to modify OVs and to discuss the challenges encountered from basic research to clinical application.