RT Journal Article
SR Electronic
T1 Relation of Cystatin C and Cathepsin B Expression to the Pathological Grade and Invasion of Human Gliomas
JF Chinese Journal of Clinical Oncology
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 303
OP 306
DO 10.1007/s11805-007-0303-5
VO 4
IS 5
A1 Fan, Kai
A1 Zhang, Yanli
A1 Song, Dawei
A1 Zhang, Yuchun
A1 Ma, Jianmei
YR 2007
UL http://www.cancerbiomed.org/content/4/5/303.abstract
AB OBJECTIVE To explore the relation of cystatin C and cathepsin B expression to the pathological grade and invasion of human gliomas.METHODS A immunohistochemical method was used to detect the expression of cystatin C and cathepsin B in 57 glioma samples.RESULTS The expression of cystatin C in high-grade (Grade III~IV )gliomas was significantly weaker than that in low-grade(Grade I~II, P=0.0001). On the other hand, the expression of cathepsin B in high-grade gliomas was significantly stronger than that in low-grade (P=0.0001). Cystatin C expression correlated inversely with cathepsin B expression in gliomas (P=0.01).CONCLUSION Cystatin C and cathepsin B expression is related to the pathological grade and invasion of gliomas. Combining detection of cystatin C and cathepsin B expressions might provide significant information for clinical assessment of maglignant phenotypes and invasion of gliomas.