PT  - JOURNAL ARTICLE
AU  - Fan, Kai
AU  - Zhang, Yanli
AU  - Song, Dawei
AU  - Zhang, Yuchun
AU  - Ma, Jianmei
TI  - Relation of Cystatin C and Cathepsin B Expression to the Pathological Grade and Invasion of Human Gliomas
AID  - 10.1007/s11805-007-0303-5
DP  - 2007 Oct 01
TA  - Chinese Journal of Clinical Oncology
PG  - 303--306
VI  - 4
IP  - 5
4099  - http://www.cancerbiomed.org/content/4/5/303.short
4100  - http://www.cancerbiomed.org/content/4/5/303.full
SO  - Cancer Biol Med2007 Oct 01; 4
AB  - OBJECTIVE To explore the relation of cystatin C and cathepsin B expression to the pathological grade and invasion of human gliomas.METHODS A immunohistochemical method was used to detect the expression of cystatin C and cathepsin B in 57 glioma samples.RESULTS The expression of cystatin C in high-grade (Grade III~IV )gliomas was significantly weaker than that in low-grade(Grade I~II, P=0.0001). On the other hand, the expression of cathepsin B in high-grade gliomas was significantly stronger than that in low-grade (P=0.0001). Cystatin C expression correlated inversely with cathepsin B expression in gliomas (P=0.01).CONCLUSION Cystatin C and cathepsin B expression is related to the pathological grade and invasion of gliomas. Combining detection of cystatin C and cathepsin B expressions might provide significant information for clinical assessment of maglignant phenotypes and invasion of gliomas.