<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fan, Kai</style></author><author><style face="normal" font="default" size="100%">Zhang, Yanli</style></author><author><style face="normal" font="default" size="100%">Song, Dawei</style></author><author><style face="normal" font="default" size="100%">Zhang, Yuchun</style></author><author><style face="normal" font="default" size="100%">Ma, Jianmei</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Relation of Cystatin C and Cathepsin B Expression to the Pathological Grade and Invasion of Human Gliomas</style></title><secondary-title><style face="normal" font="default" size="100%">Chinese Journal of Clinical Oncology</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2007</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2007-10-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">303-306</style></pages><doi><style  face="normal" font="default" size="100%">10.1007/s11805-007-0303-5</style></doi><volume><style face="normal" font="default" size="100%">4</style></volume><issue><style face="normal" font="default" size="100%">5</style></issue><abstract><style  face="normal" font="default" size="100%">OBJECTIVE To explore the relation of cystatin C and cathepsin B expression to the pathological grade and invasion of human gliomas.METHODS A immunohistochemical method was used to detect the expression of cystatin C and cathepsin B in 57 glioma samples.RESULTS The expression of cystatin C in high-grade (Grade III~IV )gliomas was significantly weaker than that in low-grade(Grade I~II, P=0.0001). On the other hand, the expression of cathepsin B in high-grade gliomas was significantly stronger than that in low-grade (P=0.0001). Cystatin C expression correlated inversely with cathepsin B expression in gliomas (P=0.01).CONCLUSION Cystatin C and cathepsin B expression is related to the pathological grade and invasion of gliomas. Combining detection of cystatin C and cathepsin B expressions might provide significant information for clinical assessment of maglignant phenotypes and invasion of gliomas.</style></abstract></record></records></xml>