PT  - JOURNAL ARTICLE
AU  - Liu, Caigang
AU  - Lu, Ping
AU  - Lu, Yang
AU  - Li, Lua
AU  - Zhang, Ruishan
AU  - Xu, Huimian
AU  - Wang, Shubao
AU  - Chen, Junqing
TI  - Clinicopathological Characteristics as Predictive Factrs for Lymph Node Metastasis in Submucosal Gastric Cancer
AID  - 10.1007/s11805-007-0237-y
DP  - 2007 Aug 01
TA  - Chinese Journal of Clinical Oncology
PG  - 237--240
VI  - 4
IP  - 4
4099  - http://www.cancerbiomed.org/content/4/4/237.short
4100  - http://www.cancerbiomed.org/content/4/4/237.full
SO  - Cancer Biol Med2007 Aug 01; 4
AB  - OBJECTIVE To identify clinicopathological characteristics as predictive factors for lymph node metastasis in submucosal gastric cancer, and in addition to establish objective criteria as indications for endoscopic submucosal dissection (ESD).METHODS Data from 130 patients with submucosal gastric cancer were collected, and the relationship between their clinicopathological characteristics and the presence of lymph node metastasis was retrospectively analyzed by multivariate analysis.RESULTS In the multivariate logistic regression model, a tumor size of 2 cm or more and an undifferentiated histologic type were found to be independent risk clinicopathological characteristics for lymph node metastasis. Among 130 patients with submucosal carcinoma, no lymph node metastases were observed in 17 patients who showed neither of the two risk clinicopathological characteristics. Lymph node metastasis occurred in 61.1% (22/36) of the patients who had both risk clinicopathological characteristics.CONCLUSION A tumor size of 2 cm or more and an undifferentiated histologic type were significantly and independently related to lymph node metastasis in submucosal gastric cancer. It is rational for the paitients with neither of these two independent risk clinicopathological characteristics to undergo an ESD.