RT Journal Article
SR Electronic
T1 Multidisciplinary team for the diagnosis and treatment of 2 cases of primary intestinal yolk sac tumor
JF Cancer Biology and Medicine
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 461
OP 467
DO 10.20892/j.issn.2095-3941.2018.0054
VO 15
IS 4
A1 Huang, Qiujuan
A1 Liu, Changxu
A1 Tang, Ruijun
A1 Li, Jie
A1 Li, Wei
A1 Zhu, Lei
A1 Guo, Yuhong
A1 Zhang, Lin
A1 Qu, Tongyuan
A1 Yang, Lingyi
A1 Li, Lingmei
A1 Wang, Yalei
A1 Sun, Baocun
A1 Meng, Bin
A1 Yan, Jie
A1 Xu, Wengui
A1 Zhang, Huilai
A1 Cao, Dengfeng
A1 Cao, Wenfeng
YR 2018
UL http://www.cancerbiomed.org/content/15/4/461.abstract
AB Extragonadal primary yolk sac tumor of the intestinal tract origin is exceedingly rare. Through a multiple disciplinary team, the diagnosis and treatment of primary intestinal yolk sac tumor were further defined. We report 2 such cases with detailed histologic and immunohistochemical analysis. The two patients were a 7-year-old girl and a 29-year-old woman. Both of them preoperatively had an elevated serum alpha fetoprotein (AFP) level (≥ 1,210 ng/mL). The tumors are located in the intestine and imaging examination indicated the rectum as the primary site. Grossly the mass was grey-white and crisp texture. Microscopic examination featured reticular, microcystic, macrocystic, papillary, solid, and some glandular patterns. Immunohistochemically, tumor cells of both cases were positive for SALL4, AFP, pan-cytokeratin (AE1/AE3), and glypican-3. Simultaneously, a stain for EMA, OCT4, CD30, HCG, vimentin and CK20 were negative in all 2 neoplasms. The features of morphology, immunohistochemistry, laboratory examinations and imaging studies consist of the diagnosis of primary yolk sac tumor of the intestine.