PT  - JOURNAL ARTICLE
AU  - Huang, Qiujuan
AU  - Liu, Changxu
AU  - Tang, Ruijun
AU  - Li, Jie
AU  - Li, Wei
AU  - Zhu, Lei
AU  - Guo, Yuhong
AU  - Zhang, Lin
AU  - Qu, Tongyuan
AU  - Yang, Lingyi
AU  - Li, Lingmei
AU  - Wang, Yalei
AU  - Sun, Baocun
AU  - Meng, Bin
AU  - Yan, Jie
AU  - Xu, Wengui
AU  - Zhang, Huilai
AU  - Cao, Dengfeng
AU  - Cao, Wenfeng
TI  - Multidisciplinary team for the diagnosis and treatment of 2 cases of primary intestinal yolk sac tumor
AID  - 10.20892/j.issn.2095-3941.2018.0054
DP  - 2018 Nov 01
TA  - Cancer Biology and Medicine
PG  - 461--467
VI  - 15
IP  - 4
4099  - http://www.cancerbiomed.org/content/15/4/461.short
4100  - http://www.cancerbiomed.org/content/15/4/461.full
SO  - Cancer Biol Med2018 Nov 01; 15
AB  - Extragonadal primary yolk sac tumor of the intestinal tract origin is exceedingly rare. Through a multiple disciplinary team, the diagnosis and treatment of primary intestinal yolk sac tumor were further defined. We report 2 such cases with detailed histologic and immunohistochemical analysis. The two patients were a 7-year-old girl and a 29-year-old woman. Both of them preoperatively had an elevated serum alpha fetoprotein (AFP) level (≥ 1,210 ng/mL). The tumors are located in the intestine and imaging examination indicated the rectum as the primary site. Grossly the mass was grey-white and crisp texture. Microscopic examination featured reticular, microcystic, macrocystic, papillary, solid, and some glandular patterns. Immunohistochemically, tumor cells of both cases were positive for SALL4, AFP, pan-cytokeratin (AE1/AE3), and glypican-3. Simultaneously, a stain for EMA, OCT4, CD30, HCG, vimentin and CK20 were negative in all 2 neoplasms. The features of morphology, immunohistochemistry, laboratory examinations and imaging studies consist of the diagnosis of primary yolk sac tumor of the intestine.