RT Journal Article
SR Electronic
T1 Therapeutic implications of cancer stem cells in prostate cancer
JF Cancer Biology & Medicine
JO Cancer Biology & Medicine
FD China Anti-Cancer Association
SP 20220714
DO 10.20892/j.issn.2095-3941.2022.0714
A1 Pinaki Banerjee
A1 Prachi Kapse
A1 Shehnaz Siddique
A1 Moumita Kundu
A1 Jasoda Choudhari
A1 Varshasnata Mohanty
A1 Diksha Malhotra
A1 Suresh W. Gosavi
A1 Rajesh N. Gacche
A1 Gopal C. Kundu
YR 2023
UL http://www.cancerbiomed.org/content/early/2023/06/05/j.issn.2095-3941.2022.0714.abstract
AB Prostate cancer, one of the most frequently occurring cancers in men, is a heterogeneous disease involving multiple cell types within tumors. This tumor heterogeneity at least partly results from genomic instability leading to sub-clonal cellular differentiation. The differentiated cell populations originate from a small subset of cells with tumor-initiating and stem-like properties. These cells, termed prostate cancer stem cells (PCSCs), play crucial roles in disease progression, drug resistance, and relapse. This review discusses the origin, hierarchy, and plasticity of PCSCs; methods for isolation and enrichment of PCSCs; and various cellular and metabolic signaling pathways involved in PCSC induction and maintenance, as well as therapeutic targeting.