TY - JOUR T1 - Facing challenges with hope: universal immune cells for hematologic malignancies JF - Cancer Biology & Medicine JO - Cancer Biology & Medicine SP - 229 LP - 247 DO - 10.20892/j.issn.2095-3941.2022.0759 VL - 20 IS - 4 AU - Yuqing Wang AU - Ruihao Huang AU - Zheng Wang AU - Jingkang Xiong AU - Xiaoqi Wang AU - Xi Zhang Y1 - 2023/04/15 UR - http://www.cancerbiomed.org/content/20/4/229.abstract N2 - Many patients have achieved a favorable overall survival rate since allogenic hematopoietic stem cell transplantation (allo-HSCT) has been widely implemented to treat hematologic malignancies. However, graft-versus-host disease (GVHD) and complications of immunosuppressive drugs after allo-HSCT are the main causes of non-relapse mortality and a poor quality of life. In addition, GVHD and infusion-induced toxicity still occur with donor lymphocyte infusions (DLIs) and chimeric antigen receptor (CAR) T-cell therapy. Because of the special immune tolerance characteristics and anti-tumor ability of universal immune cells, universal immune cell therapy may strongly reduce GVHD, while simultaneously reducing tumor burden. Nevertheless, widespread application of universal immune cell therapy is mainly restricted by poor expansion and persistence efficacy. Many strategies have been applied to improve universal immune cell proliferation and persistence efficacy, including the use of universal cell lines, signaling regulation and CAR technology. In this review we have summarized current advances in universal immune cell therapy for hematologic malignancies with a discussion of future perspectives. ER -