RT Journal Article
SR Electronic
T1 Targeted mechanical forces enhance the effects of tumor immunotherapy by regulating immune cells in the tumor microenvironment
JF Cancer Biology & Medicine
JO Cancer Biology & Medicine
FD China Anti-Cancer Association
SP 44
OP 55
DO 10.20892/j.issn.2095-3941.2022.0491
VO 20
IS 1
A1 Pengfei Zhu
A1 Hongrui Lu
A1 Mingxing Wang
A1 Ke Chen
A1 Zheling Chen
A1 Liu Yang
YR 2023
UL http://www.cancerbiomed.org/content/20/1/44.abstract
AB Mechanical forces in the tumor microenvironment (TME) are associated with tumor growth, proliferation, and drug resistance. Strong mechanical forces in tumors alter the metabolism and behavior of cancer cells, thus promoting tumor progression and metastasis. Mechanical signals are transformed into biochemical signals, which activate tumorigenic signaling pathways through mechanical transduction. Cancer immunotherapy has recently made exciting progress, ushering in a new era of “chemo-free” treatments. However, immunotherapy has not achieved satisfactory results in a variety of tumors, because of the complex tumor microenvironment. Herein, we discuss the effects of mechanical forces on the tumor immune microenvironment and highlight emerging therapeutic strategies for targeting mechanical forces in immunotherapy.