RT Journal Article
SR Electronic
T1 Translational genomics in cancer research: converting profiles into personalized cancer medicine
JF Cancer Biology and Medicine
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 214
OP 220
DO 10.7497/j.issn.2095-3941.2013.04.005
VO 10
IS 4
A1 Lalit Patel
A1 Brittany Parker
A1 Da Yang
A1 Wei Zhang
YR 2013
UL http://www.cancerbiomed.org/content/10/4/214.abstract
AB Cancer genomics is a rapidly growing discipline in which the genetic molecular basis of malignancy is studied at the scale of whole genomes. While the discipline has been successful with respect to identifying specific oncogenes and tumor suppressors involved in oncogenesis, it is also challenging our approach to managing patients suffering from this deadly disease. Specifically cancer genomics is driving clinical oncology to take a more molecular approach to diagnosis, prognostication, and treatment selection. We review here recent work undertaken in cancer genomics with an emphasis on translation of genomic findings. Finally, we discuss scientific challenges and research opportunities emerging from findings derived through analysis of tumors with high-depth sequencing.