RT Journal Article SR Electronic T1 Feasibility of sentinel lymph node biopsy omission after integration of 18F-FDG dedicated lymph node PET in early breast cancer: a prospective phase II trial JF Cancer Biology & Medicine JO Cancer Biology & Medicine FD China Anti-Cancer Association SP 1100 OP 1108 DO 10.20892/j.issn.2095-3941.2022.0085 VO 19 IS 7 A1 Junjie Li A1 Jingyi Cheng A1 Guangyu Liu A1 Yifeng Hou A1 Genghong Di A1 Benglong Yang A1 Yizhou Jiang A1 Liang Huang A1 Feilin Qu A1 Sheng Chen A1 Yan Wang A1 Keda Yu A1 Zhimin Shao YR 2022 UL http://www.cancerbiomed.org/content/19/7/1100.abstract AB Objective: Sentinel lymph node biopsy (SLNB) is currently the standard of care in clinically node negative (cN0) breast cancer. The present study aimed to evaluate the negative predictive value (NPV) of 18F-FDG dedicated lymph node positron emission tomography (LymphPET) in cN0 patients.Methods: This was a prospective phase II trial divided into 2 stages (NCT04072653). In the first stage, cN0 patients underwent axillary LymphPET followed by SLNB. In the second stage, SLNB was omitted in patients with a negative preoperative axillary assessment after integration of LymphPET. Here, we report the results of the first stage. The primary outcome was the NPV of LymphPET to detect macrometastasis of lymph nodes (LN-macro).Results: A total of 189 patients with invasive breast cancer underwent LymphPET followed by surgery with definitive pathological reports. Forty patients had LN-macro, and 16 patients had only lymph node micrometastasis. Of the 131 patients with a negative LymphPET result, 16 patients had LN-macro, and the NPV was 87.8%. After combined axillary imaging evaluation with ultrasound and LymphPET, 100 patients were found to be both LymphPET and ultrasound negative, 9 patients had LN-macro, and the NPV was 91%.Conclusions: LymphPET can be used to screen patients to potentially avoid SLNB, with an NPV > 90%. The second stage of the SOAPET trial is ongoing to confirm the safety of omission of SLNB according to preoperational axillary evaluation integrating LymphPET.