RT Journal Article
SR Electronic
T1 Clinical Pathological Analysis of Synovial Sarcoma
JF Chinese Journal of Clinical Oncology
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 246
OP 249
DO 10.1007/s11805-007-0246-x
VO 4
IS 4
A1 Ling Yang
A1 Bogen Song
A1 zhongjie Lin
A1 Weiming Zhang
A1 Qinhe Fan
YR 2007
UL http://www.cancerbiomed.org/content/4/4/246.abstract
AB OBJECTIVE To investigate the clinical diagnosis and differential diagnosis of synovial sarcoma (SS).METHODS A total of 41 paraffin-embedded synovial sarcoma samples were examined by H&E staining, immunohistochemistry staining and the reverse transcriptase polymerase chain reaction (RT-PCR), in order to provide a scientific bases for diagnosis and differential diagnosis.RESULTS Twelve cases were a biphasic type, 22 cases were a monophasic fibrous type, and 7 cases were a poorly differentiated type. Thirty-six cases were both CK (and/or EMA) and Vim positive. Five cases were only Vim positive. A SYT-SSX fusion gene was detected in 18 cases by RT-PCR.CONCLUSION By observation of the histomorphology, immunohistochemistry markers and detection of a SYT-SSX fusion gene, we can make a clinical pathological diagnosis of synovial sarcoma.