PT  - JOURNAL ARTICLE
AU  - Yang, Ling
AU  - Song, Bogen
AU  - Lin, zhongjie
AU  - Zhang, Weiming
AU  - Fan, Qinhe
TI  - Clinical Pathological Analysis of Synovial Sarcoma
AID  - 10.1007/s11805-007-0246-x
DP  - 2007 Aug 01
TA  - Chinese Journal of Clinical Oncology
PG  - 246--249
VI  - 4
IP  - 4
4099  - http://www.cancerbiomed.org/content/4/4/246.short
4100  - http://www.cancerbiomed.org/content/4/4/246.full
SO  - Cancer Biol Med2007 Aug 01; 4
AB  - OBJECTIVE To investigate the clinical diagnosis and differential diagnosis of synovial sarcoma (SS).METHODS A total of 41 paraffin-embedded synovial sarcoma samples were examined by H&E staining, immunohistochemistry staining and the reverse transcriptase polymerase chain reaction (RT-PCR), in order to provide a scientific bases for diagnosis and differential diagnosis.RESULTS Twelve cases were a biphasic type, 22 cases were a monophasic fibrous type, and 7 cases were a poorly differentiated type. Thirty-six cases were both CK (and/or EMA) and Vim positive. Five cases were only Vim positive. A SYT-SSX fusion gene was detected in 18 cases by RT-PCR.CONCLUSION By observation of the histomorphology, immunohistochemistry markers and detection of a SYT-SSX fusion gene, we can make a clinical pathological diagnosis of synovial sarcoma.