RT Journal Article
SR Electronic
T1 Anti-tumor pharmacology of natural products targeting mitosis
JF Cancer Biology & Medicine
JO Cancer Biology & Medicine
FD China Anti-Cancer Association
SP 774
OP 801
DO 10.20892/j.issn.2095-3941.2022.0006
VO 19
IS 6
A1 Manru Huang
A1 Caiyan Liu
A1 Yingying Shao
A1 Shiyue Zhou
A1 Gaoyong Hu
A1 Shuangshuang Yin
A1 Weiling Pu
A1 Haiyang Yu
YR 2022
UL http://www.cancerbiomed.org/content/19/6/774.abstract
AB Cancer has been an insurmountable problem in the history of medical science. The uncontrollable proliferation of cancer cells is one of cancer’s main characteristics, which is closely associated with abnormal mitosis. Targeting mitosis is an effective method for cancer treatment. This review summarizes several natural products with anti-tumor effects related to mitosis, focusing on targeting microtubulin, inducing DNA damage, and modulating mitosis-associated kinases. Furthermore, the main disadvantages of several typical compounds, including drug resistance, toxicity to non-tumor tissues, and poor aqueous solubility and pharmacokinetic properties, are also discussed, together with strategies to address them. Improved understanding of cancer cell mitosis and natural products may pave the way to drug development for the treatment of cancer.