TY - JOUR T1 - Advances in lung cancer screening and early detection JF - Cancer Biology & Medicine JO - Cancer Biology & Medicine SP - 591 LP - 608 DO - 10.20892/j.issn.2095-3941.2021.0690 VL - 19 IS - 5 AU - Caichen Li AU - Huiting Wang AU - Yu Jiang AU - Wenhai Fu AU - Xiwen Liu AU - Ran Zhong AU - Bo Cheng AU - Feng Zhu AU - Yang Xiang AU - Jianxing He AU - Wenhua Liang Y1 - 2022/05/15 UR - http://www.cancerbiomed.org/content/19/5/591.abstract N2 - Lung cancer is associated with a heavy cancer-related burden in terms of patients’ physical and mental health worldwide. Two randomized controlled trials, the US-National Lung Screening Trial (NLST) and Nederlands-Leuvens Longkanker Screenings Onderzoek (NELSON), indicated that low-dose CT (LDCT) screening results in a statistically significant decrease in mortality in patients with lung cancer, LDCT has become the standard approach for lung cancer screening. However, many issues in lung cancer screening remain unresolved, such as the screening criteria, high false-positive rate, and radiation exposure. This review first summarizes recent studies on lung cancer screening from the US, Europe, and Asia, and discusses risk-based selection for screening and the related issues. Second, an overview of novel techniques for the differential diagnosis of pulmonary nodules, including artificial intelligence and molecular biomarker-based screening, is presented. Third, current explorations of strategies for suspected malignancy are summarized. Overall, this review aims to help clinicians understand recent progress in lung cancer screening and alleviate the burden of lung cancer. ER -