TY - JOUR T1 - Immunology and immunotherapy in breast cancer JF - Cancer Biology & Medicine JO - Cancer Biology & Medicine SP - 609 LP - 618 DO - 10.20892/j.issn.2095-3941.2021.0597 VL - 19 IS - 5 AU - Vladimir Semiglazov AU - Andrey Tseluiko AU - Asel Kudaybergenova AU - Anna Artemyeva AU - Petr Krivorotko AU - Roman Donskih Y1 - 2022/05/15 UR - http://www.cancerbiomed.org/content/19/5/609.abstract N2 - Immuno-oncology is a rapidly developing field in medicine. Drug combination therapies have already been studied in many clinical trials on various tumor types. In recent years, a checkpoint inhibition therapy with monoclonal antibodies targeting PD-1 and its ligand PD-L1 has been developed. Breast cancer had been examined in the field of immune-oncology relatively recently. This review focuses on clinical evidence regarding immune checkpoint inhibition for curative treatment of various breast cancer subtypes. In addition, we present the results of studies demonstrating the prognostic and predictive value of levels of tumor-infiltrating lymphocytes (CD4 and CD8), their quantitative ratios, and their correlation with regulatory genes (PD-1, PD-L1, and FOX-P3). ER -