RT Journal Article
SR Electronic
T1 The Wnt/β-catenin signaling pathway in the tumor microenvironment of hepatocellular carcinoma
JF Cancer Biology & Medicine
JO Cancer Biology & Medicine
FD China Anti-Cancer Association
SP 305
OP 318
DO 10.20892/j.issn.2095-3941.2021.0306
VO 19
IS 3
A1 Kaiting Wang
A1 Xinyao Qiu
A1 Yan Zhao
A1 Hongyang Wang
A1 Lei Chen
YR 2022
UL http://www.cancerbiomed.org/content/19/3/305.abstract
AB The Wnt/β-catenin signaling pathway regulates many aspects of tumor biology, and many studies have focused on the role of this signaling pathway in tumor cells. However, it is now clear that tumor development and metastasis depend on the two-way interaction between cancer cells and their environment, thereby forming a tumor microenvironment (TME). In this review, we discuss how Wnt/β-catenin signaling regulates cross-interactions among different components of the TME, including immune cells, stem cells, tumor vasculature, and noncellular components of the TME in hepatocellular carcinoma. We also investigate their preclinical and clinical insights for primary liver cancer intervention, and explore the significance of using Wnt/β-catenin mutations as a biomarker to predict resistance in immunotherapy.