TY - JOUR T1 - Cancer metabolism and dietary interventions JF - Cancer Biology & Medicine JO - Cancer Biol Med SP - 163 LP - 174 DO - 10.20892/j.issn.2095-3941.2021.0461 VL - 19 IS - 2 AU - Lin Qian AU - Fan Zhang AU - Miao Yin AU - Qunying Lei Y1 - 2022/02/01 UR - http://www.cancerbiomed.org/content/19/2/163.abstract N2 - Metabolic remodeling is a key feature of cancer development. Knowledge of cancer metabolism has greatly expanded since the first observation of abnormal metabolism in cancer cells, the so-called Warburg effect. Malignant cells tend to modify cellular metabolism to favor specialized fermentation over the aerobic respiration usually used by most normal cells. Thus, targeted cancer therapies based on reprogramming nutrient or metabolite metabolism have received substantial attention both conceptually and in clinical practice. In particular, the management of nutrient availability is becoming more attractive in cancer treatment. In this review, we discuss recent findings on tumor metabolism and potential dietary interventions based on the specific characteristics of tumor metabolism. First, we present a comprehensive overview of changes in macronutrient metabolism. Carbohydrates, amino acids, and lipids, are rewired in the cancer microenvironment individually or systematically. Second, we summarize recent progress in cancer interventions applying different types of diets and specific nutrient restrictions in pre-clinical research or clinical trials. ER -