RT Journal Article
SR Electronic
T1 Examining heterogeneity of stromal cells in tumor microenvironment based on pan-cancer single-cell RNA sequencing data
JF Cancer Biology & Medicine
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 30
OP 42
DO 10.20892/j.issn.2095-3941.2020.0762
VO 19
IS 1
A1 Wenhui Wang
A1 Li Wang
A1 Junjun She
A1 Jun Zhu
YR 2022
UL http://www.cancerbiomed.org/content/19/1/30.abstract
AB Tumor tissues contain both tumor and non-tumor cells, which include infiltrated immune cells and stromal cells, collectively called the tumor microenvironment (TME). Single-cell RNA sequencing (scRNAseq) enables the examination of heterogeneity of tumor cells and TME. In this review, we examined scRNAseq datasets for multiple cancer types and evaluated the heterogeneity of major cell type composition in different cancer types. We further showed that endothelial cells and fibroblasts/myofibroblasts in different cancer types can be classified into common subtypes, and the subtype composition is clearly associated with cancer characteristic and therapy response.