PT  - JOURNAL ARTICLE
AU  - LI, Yong
AU  - GUO, Zhi
AU  - GUO, Xiu-ying
AU  - WANG, Zhe
AU  - XING, Wen-ge
TI  - Influence of Vein Injury in Different Methods of Chemotherapy in Mice
AID  - 10.1007/s11805-011-0566-8
DP  - 2011 Jun 01
TA  - Clinical Oncology and Cancer Research
PG  - 100--105
VI  - 8
IP  - 2
4099  - http://www.cancerbiomed.org/content/8/2/100.short
4100  - http://www.cancerbiomed.org/content/8/2/100.full
SO  - Cancer Biol Med2011 Jun 01; 8
AB  - OBJECTIVE To explore the effects of cisplatin chemotherapy via the vein and the abdominal cavity on the functions of endothelial cells of mice with non-small cell lung cancer.METHODS 75 mice were divided equally into a untreated group, a group treated with chemotherapy (cisplatin: 2 mg/kg, 0.5 mL) via an intravenous method and a group treated with chemotherapy (cisplatin: 2 mg/kg, 0.5 mL) via an intraperitoneal method; changes in the morphology and ultrastructure of vein endothelial cells were observed.RESULTS The injury of the intima of the intravenous chemotherapy group was similar to that of the intraperitoneal chemotherapy group.CONCLUSION The injury of vein endothelial cells is not significantly related to the choice of intravenous injection or intraperitoneal injection.