@article {Xu966, author = {Zhengli Xu and Xiaojun Huang}, title = {Cellular immunotherapy for hematological malignancy: recent progress and future perspectives}, volume = {18}, number = {4}, pages = {966--980}, year = {2021}, doi = {10.20892/j.issn.2095-3941.2020.0801}, publisher = {Cancer Biology \& Medicine}, abstract = {Advancements in the field of cellular immunotherapy have accelerated in recent years and have changed the treatment landscape for a variety of hematologic malignancies. Cellular immunotherapy strategies exploit the patient{\textquoteright}s immune system to kill cancer cells. The successful use of CD19 chimeric antigen receptor (CAR) T-cells in treating B-cell malignancies is the paradigm of this revolution, and numerous ongoing studies are investigating and extending this approach to other malignancies. However, resistance to CAR-T-cell therapy and non-durable efficacy have prevented CAR-T-cells from becoming the ultimate therapy. Because natural killer (NK) cells play an essential role in antitumor immunity, adoptively transferred allogeneic NK and CAR-modified NK cell therapy has been attempted in certain disease subgroups. Allogenic hematopoietic stem cell transplantation (allo-HSCT) is the oldest form of cellular immunotherapy and the only curative option for hematologic malignancies. Historically, the breadth of application of allo-HSCT has been limited by a lack of identical sibling donors (ISDs). However, great strides have recently been made in the success of haploidentical allografts worldwide, which enable everyone to have a donor. Haploidentical donors can achieve comparable outcomes to those of ISDs and even better outcomes in certain circumstances because of a stronger graft vs. tumor effect. Currently, novel strategies such as CAR-T or NK-based immunotherapy can be applied as a complement to allo-HSCT for curative effects, particularly in refractory cases. Here, we introduce the developments in cellular immunotherapy in hematology.}, issn = {2095-3941}, URL = {https://www.cancerbiomed.org/content/18/4/966}, eprint = {https://www.cancerbiomed.org/content/18/4/966.full.pdf}, journal = {Cancer Biology \& Medicine} }