PT  - JOURNAL ARTICLE
AU  - Liang, Jun
TI  - The Effect of Genetic Polymorphism upon Antineoplastic Sensitivity
DP  - 2006 Dec 01
TA  - Chinese Journal of Clinical Oncology
PG  - 381--385
VI  - 3
IP  - 6
4099  - http://www.cancerbiomed.org/content/3/6/381.short
4100  - http://www.cancerbiomed.org/content/3/6/381.full
SO  - Cancer Biol Med2006 Dec 01; 3
AB  - In clinical practice, patients undergoing chemotherapy display prominent Individual differences, adverse reactions and sensitivity to antineoplastic therapy. Those differences are caused by individual genetic polymorphism of related genes. Genetic variation can Induce distinct alterations of drugmetabolizing enzymes, drug transporters, drug targets and DNA repair enzymes and thereby Influence the ability of the drugs to reach their target sites. This article reviews In detail the potential interactions mentioned above.