<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Liang, Jun</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Genetic Polymorphism upon Antineoplastic Sensitivity</style></title><secondary-title><style face="normal" font="default" size="100%">Chinese Journal of Clinical Oncology</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2006</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2006-12-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">381-385</style></pages><volume><style face="normal" font="default" size="100%">3</style></volume><issue><style face="normal" font="default" size="100%">6</style></issue><abstract><style  face="normal" font="default" size="100%">In clinical practice, patients undergoing chemotherapy display prominent Individual differences, adverse reactions and sensitivity to antineoplastic therapy. Those differences are caused by individual genetic polymorphism of related genes. Genetic variation can Induce distinct alterations of drugmetabolizing enzymes, drug transporters, drug targets and DNA repair enzymes and thereby Influence the ability of the drugs to reach their target sites. This article reviews In detail the potential interactions mentioned above.</style></abstract></record></records></xml>