PT  - JOURNAL ARTICLE
AU  - Song, Yan
AU  - Xiao, Juxiang
AU  - Fang, Wentao
AU  - Lu, Ping
AU  - Fan, Qingxia
AU  - Shu, Yongqian
AU  - Feng, Jifeng
AU  - Zhang, Shu
AU  - Ba, Yi
AU  - Zhao, Yang
AU  - Liu, Ying
AU  - Bai, Chunmei
AU  - Bai, Yuxian
AU  - Tang, Yong
AU  - He, Jie
AU  - Huang, Jing
TI  - The relationship between treatment-induced hypertension and efficacy of anlotinib in recurrent or metastatic esophageal squamous cell carcinoma
AID  - 10.20892/j.issn.2095-3941.2020.0187
DP  - 2021 May 01
TA  - Cancer Biology and Medicine
PG  - 562--568
VI  - 18
IP  - 2
4099  - http://www.cancerbiomed.org/content/18/2/562.short
4100  - http://www.cancerbiomed.org/content/18/2/562.full
SO  - Cancer Biol Med2021 May 01; 18
AB  - Objective: In this post-hoc analysis, we evaluated anlotinib treatment-induced hypertension as a potential predictive factor of efficacy in esophageal squamous cell carcinoma (ESCC) patients.Methods: A total of 109 patients enrolled in the anlotinib group in a phase 2 trial were included. The tumor response was assessed by computed tomography at week 3, week 6, and then every 6 weeks until progressive disease was observed. The primary endpoint of the study was progression free survival (PFS). The secondary endpoints included overall survival (OS) and objective response rate (ORR).Results: In all patients, the median PFS was 3.02 months [95% confidence interval (CI): 2.63–3.65 months] and the OS was 6.11 months (95% CI: 4.40–7.79 months). The ORR was 7.34% (95% CI: 3.22%–13.95%). A total of 59 (54%) patients were diagnosed with treatment-induced hypertension (Group A), and the remaining patients (n = 50, 46%) were in Group B. Baseline prognostic factors were similar between the 2 groups. Patients in Group A had a longer PFS and OS and higher ORR. When stratifying patients using a previously known history of hypertension, treatment-induced hypertension was a predictor only for patients without previous hypertension, who had longer PFS [hazard ratio (HR): 0.40, 95% CI: 0.24–0.68] and OS (HR: 0.37, 95% CI: 0.21–0.67).Conclusions: We showed, for the first time, a correlation between treatment-induced hypertension and better prognoses in recurrent or metastatic ESCC patients treated with anlotinib, without a previously known history of hypertension. Treatment-induced hypertension may be a simple and low cost predictor for anlotinib antitumor efficacy in these patients, which may also reflect the intended target inhibition.