RT Journal Article
SR Electronic
T1 HRCT Scans of Peripheral Non-Small Cell Lung Cancers and their Relationship with Cyclin D1 Expression: a Longitudinal Study
JF Chinese Journal of Clinical Oncology
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 172
OP 178
DO 10.1007/s11805-008-0172-6
VO 5
IS 3
A1 Ma, Shuhua
A1 Wu, Linfa
A1 Xu, Xiaomao
A1 Le, Hongbo
A1 Cheng, Xiaoling
A1 Zhang, Huihong
A1 Sun, Zhengyu
A1 Wang, Zhaoxin
A1 Wu, Min
A1 Mei, Wei
A1 Hu, Zhiguo
A1 Li, Yuguang
YR 2008
UL http://www.cancerbiomed.org/content/5/3/172.abstract
AB OBJECTIVE To investigate cyclin D1 expression in peripheral lung cancers and its relationship with CT signs and prognosis.METHODS Cyclin D1 expression in peripheral lung cancers and its relationship with the CT imaging and prognosis were analyzed retrospectively by means of SP immunohistochemistry and spiral CT scanning in 92 patients with peripheral lung cancer verified by pathology.RESULTS Cyclin D1 expression was related to deep lobulation, spiculate protuberance, short thin spinules sign and mediastina lymph node metastasis. Cyclin D1 expression was not related to tumor size, cavity, pleural indentation, histological type, differentiation, tumor TNM stage, age or sex. Cyclin D1 was a negative prognostic factor whose over-expression indicated a poor prognosis.CONCLUSION Cyclin D1 expression may play an important role in the occurrence, progress and CT scan results of lung cancers. Cyclin D1 was a negative factor whose over-expression implied a poor prognosis. Detection of the cyclin D1 and observation of the CT scan can be considered as indexes of clinical diagnosis and prognostic evaluation.