<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zhang, Weihua</style></author><author><style face="normal" font="default" size="100%">Wang, Xudong</style></author><author><style face="normal" font="default" size="100%">Xie, Xiaodong</style></author><author><style face="normal" font="default" size="100%">Guo, Fengxia</style></author><author><style face="normal" font="default" size="100%">Yang, Rong</style></author><author><style face="normal" font="default" size="100%">Liu, Yuhua</style></author><author><style face="normal" font="default" size="100%">Xu, Shijian</style></author><author><style face="normal" font="default" size="100%">Yang, Yajun</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Association of the p73 Gene G4C14-to-A4T14 Polymorphism with Increased Gastric Cancer Risk in a Northwestern Chinese Population</style></title><secondary-title><style face="normal" font="default" size="100%">Chinese Journal of Clinical Oncology</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2008</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2008-06-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">157-160</style></pages><doi><style  face="normal" font="default" size="100%">10.1007/s11805-008-0157-5</style></doi><volume><style face="normal" font="default" size="100%">5</style></volume><issue><style face="normal" font="default" size="100%">3</style></issue><abstract><style  face="normal" font="default" size="100%">OBJECTIVE To evaluate the p73 gene G4C14-to-A4T14 double nucleotide polymorphism with both increased gastric cancer (GC) risk and different histological subtypes of GC in a northwestern Chinese population.METHODS Genotyping of the polymorphism of the p73 gene was conducted with PCR-CTPP.RESULTS All 385 GC patients including 305 diffuse-type and 80 intestinal-type cases and 412 healthy controls were investigated. The frequencies of p73 AT/AT, AT/GC, and GC/GC genotypes were 28.1%, 47.1%, and 24.8% in the controls, and were 22.0%, 45.0%, and 33.0% in GC cases respectively; the GC/GC homozygote frequency was higher in GC cases, mainly in diffuse type compared to the controls with OR = 1.71 (1.16~2.51) and 1.87 (95% CI, 1.24~2.81) respectively. The results showed that carriers of the p73 G4A GC/GC homozygote had a 1.71-time higher risk of GC, especially of the diffuse-type GC compared to the controls. The carriers of the AT/GC heterozygote also had a slightly increased risk of GC cancer, mainly on intestinal-type GC. This is the first report that the p73 G4A double-nucleotide polymorphism is associated with an increased risk of diffuse-type gastric cancer.CONCLUTION The p73 G4A GC/GC genotype is associated with an increased risk of gastric cancer, especially of the GC diffuse-type.</style></abstract></record></records></xml>