<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Han, Yanchun</style></author><author><style face="normal" font="default" size="100%">Liu, Luying</style></author><author><style face="normal" font="default" size="100%">Yan, Dongxia</style></author><author><style face="normal" font="default" size="100%">Wang, Guihua</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Correlation between Expression of P38 MAPK-Signaling and uPA in Breast Cancer</style></title><secondary-title><style face="normal" font="default" size="100%">Chinese Journal of Clinical Oncology</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2008</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2008-06-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">161-164</style></pages><doi><style  face="normal" font="default" size="100%">10.1007/s11805-008-0161-9</style></doi><volume><style face="normal" font="default" size="100%">5</style></volume><issue><style face="normal" font="default" size="100%">3</style></issue><abstract><style  face="normal" font="default" size="100%">OBJECTIVE To study the expression of phosphorylated p38 mitogen-activated protein kinase (p-p38) and uPA and the correlation of their expression with breast cancer clinicopathological characteristics, and to investigate the role of the p38MAPK-signaling pathway in regulating uPA expression in breast cancer cells.METHODS Immunohistochemistry (S-P) was used to test the expression of p-p38 and uPA in 60 specimens of breast cancer tissues. Western blots were adopted to detect expression of the p-p38 and uPA proteins in MDA-MB-231 and MCF-7 breast cancer cells, and uPA expression after treatment with SB203580, a specific inhibitor of p38 MAPK.RESULTS The positive rate of the p-p38 protein and uPA protein expression in the breast cancer tissues was 56.7% and 60.0%,respectively. The expression of p-p38 was positively related to the expression of uPA (r = 0.316, P &lt; 0.05). The expression of p-p38 and uPA was related to lymph node metastasis and the TNM stage (P &lt; 0.05), but it was not related to the patient’s age or tumor size (P &gt; 0.05). The expression of p-p38 and uPA in MDA-MB-231 cells was higher than that in MCF-7 cells. SB203580 inhibited the p38 MAPK pathway and reduced uPA protein expression.CONCLUSION The p38 MAPK-signaling pathway promotes breast cancer malignant progression by up-regulating uPA expression, and it may be an important process in breast cancer invasion and metastasis.</style></abstract></record></records></xml>