PT - JOURNAL ARTICLE AU - Tian, Guihong AU - Zhou, Ling AU - Zhong, Ying AU - Xu, Wan AU - Bai, Hong AU - Liu, Lu AU - Cui, Shuxiang TI - Experimental Studies of the Therapeutic Effect of <em>Gypsophila Oldhamiana</em> Gypsogenin on Lewis Lung Cancer in Mice AID - 10.1007/s11805-008-0206-0 DP - 2008 Jun 01 TA - Chinese Journal of Clinical Oncology PG - 206--210 VI - 5 IP - 3 4099 - http://www.cancerbiomed.org/content/5/3/206.short 4100 - http://www.cancerbiomed.org/content/5/3/206.full SO - Cancer Biol Med2008 Jun 01; 5 AB - OBJECTIVE To observe the inhibitory effect of Gypsophila oldhamiana gypsogenin (GOG) on Lewis lung cancer growth, and to investigate the mechanism of its anti-tumor effect.METHODS A mouse model bearing Lewis lung cancer was used. The 5 experimental groups were divided into a positive control (cis-diaminedichloroplatinum), a negative control, and high, medium and low-GOG dosage groups. The inhibitory action of GOG administration on the lung cancer was observed. After GOG treatment, the lungs were taken out and a lung coefficient computed. The expressions of VEGF, Bcl-2, Bax and P53 in the cancers were determined using immunohistochemical staining.RESULTS The tumor weight of the mice given various doses of GOG was significantly lower compared to the negative-control group (P &lt; 0.01), and the lung coefficient of the groups given high and low GOG doses was significantly lower compared to the negative-control group (P &lt; 0.01). Immunohistochemical results were shown as follows: i) The VEGF and Bcl-2 expressions in the GOG groups were significantly lower than that of the negative-control group (P &lt; 0.05); ii) Bax expression in the groups treated with high and medium GOG doses was significantly higher compared to the negative-control group (P &lt; 0.05); iii) The mutant P53 expression in the GOG-treated groups was significantly lower compared to the negative-control group (P &lt; 0.05).CONCLUSION GOG can inhibit the growth and metastasis of Lewis lung cancer, and may exert its mechanism of tumor control by inhibition of tumor angiogenesis and induction of apoptosis.