RT Journal Article
SR Electronic
T1 Clinicopathological Significance of E-cadherin and PCNA Expression in Hunman Non-small Cell Lung Cancer
JF Chinese Journal of Clinical Oncology
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 87
OP 92
DO 10.1007/s11805-008-0087-2
VO 5
IS 2
A1 Ma, Jianwei
A1 Fan, Kai
A1 Zhang, Yanli
A1 Song, Dawei
A1 Ma, Jianmei
YR 2008
UL http://www.cancerbiomed.org/content/5/2/87.abstract
AB OBJECTIVE This study was designed to assess E-cadherin (E-cad) and proliferating cell nuclear antigen (PCNA) expression as well as their clinicopathological significance in hunman nonsmall cell lung cancers (NSCLCs). Possible molecular mechanisms of differentiation and metastasis of NSCLCs are discussed.METHODS Immunohistochemical and immunofluorescence double staining were performed to examine the expression of E-cad and PCNA in 68 primary NSCLCs cases.RESULTS The E-cad expression in squamous cell carcinomas and adenocarcinomas showed no significant difference. E-cad expression had a positive correlation with the histological-differentiated grade. A significant difference of E-cad expression was found between metastatic and non-metastatic groups. PCNA expression in squamous cell carcinomas and adenocarcinomas showed no significant difference. The PCNA expression had a reverse correlation with the histological-differentiated grade. A significant difference of PCNA expression was found between metastatic and non-metastatic groups. The E-cad and PCNA expression presented a reverse correlation.CONCLUSION E-cad expression is not associated with the histological type of NSCLC, but is associated with differentiation and metastasis of the cancer. Down-regulation of E-cad expression affects the proliferation of cancer cells. Conjoint analysis of E-cad and PCNA expression is a good way to evaluate tumor biological behavior.