PT  - JOURNAL ARTICLE
AU  - Wu, Changli
AU  - Zhang, Wenlan
AU  - Chang, Jiwu
AU  - Zhao, Zuohui
AU  - Sun, Guang
AU  - Han, Ruifa
TI  - MDRl/P-Glycoprotein Overexpression in Bladder Transitional Cell Carcinoma and its Correlation with Expression of Survivin and Fas
DP  - 2006 Jun 01
TA  - Chinese Journal of Clinical Oncology
PG  - 191--195
VI  - 3
IP  - 3
4099  - http://www.cancerbiomed.org/content/3/3/191.short
4100  - http://www.cancerbiomed.org/content/3/3/191.full
SO  - Cancer Biol Med2006 Jun 01; 3
AB  - OBJECTIVE To explore the expression of the MDR1/P-glycoprotein, Fas and survivin and to examine their correlation with the biologic behavior of bladder transitional cell carcinoma (BTCC)METHODS Immunohistochemistry was used to examine the expression of P-gp, survivin and Fas in BTCC (n=64) and normal bladder mucosa (n=12).RESULTS The expression level of P-gp and survivin in BTCC was higher compared to normal bladder mucosa (P<0.01) and their expression was strongly correlated with clinical grading (P<0.01). In BTCC and normal bladder mucosa Fas expression was 50% and 100%, respectively (P< 0.01). Recurrent BTCC showed higher expression than primary BTCC (P< 0.01) and the expression of P-gp in BTCC had a reverse correlation with Fas expression but no correlation with survivin expression.CONCLUSION The MDR of BTCC was strongly correlated with the expression of P-gp and Fas, but was not correlated with survivin expression. Thus, enhancing cancer sensitivity to chemotherapy by reversing multidrug resistance with reversal agents or up-regulating Fas expression by apoptotic enhancing agents, might be a potential therapy to prevent tumor recurrence and invasiveness.