RT Journal Article
SR Electronic
T1 Preliminary Study of Oxidative Stress in Human Hepatocellular Carcinoma and Adjacent Normal Liver Tissues
JF Chinese Journal of Clinical Oncology
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 11
OP 14
VO 3
IS 1
A1 Hongwei Yu
A1 Chunying Chen
A1 Jiangxue Wang
A1 Yuxi Gao
A1 Guilong Deng
A1 Yingbin Liu
A1 Shuyou Peng
A1 Zhifang Chai
YR 2006
UL http://www.cancerbiomed.org/content/3/1/11.abstract
AB OBJECTIVE The antioxidative system in human hepatocellular carcinoma was investigated.METHODS The activities of cytosolic catalase (CAT), superoxide dismutase, glutathione peroxidase (GSH-Px), glutathione S-tranferase and levels of reduced glutathione, total protein thiols and malondialdehyde were assayed in 10 cases of hepatocellular carcinoma and adjacent normal liver.RESULTS Hepatoma tissues showed higher activities of CAT, GSH-Px and lower content of total antioxidative capacity compared to adjacent normal liver tissue (P<0.05).CONCLUSION These findings suggest that the antioxidative defense-related enzymes and antioxidants are largely regulated in hepatoma cells. However, the mechanism which is not clear requires further investigation.