PT  - JOURNAL ARTICLE
AU  - Hongwei Yu
AU  - Chunying Chen
AU  - Jiangxue Wang
AU  - Yuxi Gao
AU  - Guilong Deng
AU  - Yingbin Liu
AU  - Shuyou Peng
AU  - Zhifang Chai
TI  - Preliminary Study of Oxidative Stress in Human Hepatocellular Carcinoma and Adjacent Normal Liver Tissues
DP  - 2006 Feb 01
TA  - Chinese Journal of Clinical Oncology
PG  - 11--14
VI  - 3
IP  - 1
4099  - http://www.cancerbiomed.org/content/3/1/11.short
4100  - http://www.cancerbiomed.org/content/3/1/11.full
SO  - Cancer Biol Med2006 Feb 01; 3
AB  - OBJECTIVE The antioxidative system in human hepatocellular carcinoma was investigated.METHODS The activities of cytosolic catalase (CAT), superoxide dismutase, glutathione peroxidase (GSH-Px), glutathione S-tranferase and levels of reduced glutathione, total protein thiols and malondialdehyde were assayed in 10 cases of hepatocellular carcinoma and adjacent normal liver.RESULTS Hepatoma tissues showed higher activities of CAT, GSH-Px and lower content of total antioxidative capacity compared to adjacent normal liver tissue (P<0.05).CONCLUSION These findings suggest that the antioxidative defense-related enzymes and antioxidants are largely regulated in hepatoma cells. However, the mechanism which is not clear requires further investigation.