PT  - JOURNAL ARTICLE
AU  - Ning Li
AU  - Xiaobing Chen
AU  - Xiangbin Wan
AU  - Suxia Luo
AU  - Lili Han
AU  - Mengqiang Zhou
AU  - Dengwen Yin
AU  - Li Zhang
TI  - Relationship between Expression of CEA, E-cadherin and Liver Metastasis in Colorectal Cancer
AID  - 10.1007/s11805-008-0429-0
DP  - 2008 Dec 01
TA  - Chinese Journal of Clinical Oncology
PG  - 429--432
VI  - 5
IP  - 6
4099  - http://www.cancerbiomed.org/content/5/6/429.short
4100  - http://www.cancerbiomed.org/content/5/6/429.full
SO  - Cancer Biol Med2008 Dec 01; 5
AB  - OBJECTIVE To investigate the expression of E-cadherin and CEA in serum in colorectal carcinoma and their relationship with liver metastasis.METHODS CEA level was measured post-operatively by radioimmunoassay of 60 patients with colorectal cancer. Immunohistochemical analysis was used to evaluate the expression of E-cadherin.RESULTS In liver metastasis group, 24 patients (24/26, 92.3%) were high level of CEA, but only 9 patients in non-liver metastasis group. The difference is significant (P = 0.004). Expression of E-cadherin significantly correlated with differentiation, but was not associated with T stage or N stage. Liver metastatic rate in negative expression was higher than that in positive expression. And the survival analysis showed that time of liver metastasis was significant different in two groups (P < 0.05).CONCLUSION The expression of CEA in serum can be used to predict liver mestatasis of colorectal cancer after operation. E-cadherin, associated with tumor differentiation, is also a hopeful indicator for the prediction of liver metastasis in patients with colorectal cancer.