RT Journal Article
SR Electronic
T1 Expression of Angiotensin II and Aldosterone in Radiation-induced Lung Injury
JF Cancer Biology and Medicine
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 254
OP 260
DO 10.7497/j.issn.2095-3941.2012.04.006
VO 9
IS 4
A1 Shuo Cao
A1 Rong Wu
YR 2012
UL http://www.cancerbiomed.org/content/9/4/254.abstract
AB Objective Radiation-induced lung injury (RILI) is the most common, dose-limiting complication in thoracic malignancy radiotherapy. Considering its negative impact on patients and restrictions to efficacy, the mechanism of RILI was studied.Methods Wistar rats were locally irradiated with a single dose of 0, 16, and 20 Gy to the right half of the lung to establish a lung injury model. Two and six months after irradiation, the right half of the rat lung tissue was removed, and the concentrations of TGF-β1, angiotensin II, and aldosterone were determined via enzyme-linked immunosorbent assay.Results Statistical differences were observed in the expression levels of angiotensin II and aldosterone between the non-irradiation and irradiation groups. Moreover, the expression level of the angiotensin II-aldosterone system increased with increasing doses, and the difference was still observed as time progressed.Conclusions Angiotensin II-aldosterone system has an important pathophysiological function in the progression of RILI.