PT  - JOURNAL ARTICLE
AU  - Shuo Cao
AU  - Rong Wu
TI  - Expression of Angiotensin II and Aldosterone in Radiation-induced Lung Injury
AID  - 10.7497/j.issn.2095-3941.2012.04.006
DP  - 2012 Dec 01
TA  - Cancer Biology and Medicine
PG  - 254--260
VI  - 9
IP  - 4
4099  - http://www.cancerbiomed.org/content/9/4/254.short
4100  - http://www.cancerbiomed.org/content/9/4/254.full
SO  - Cancer Biol Med2012 Dec 01; 9
AB  - Objective Radiation-induced lung injury (RILI) is the most common, dose-limiting complication in thoracic malignancy radiotherapy. Considering its negative impact on patients and restrictions to efficacy, the mechanism of RILI was studied.Methods Wistar rats were locally irradiated with a single dose of 0, 16, and 20 Gy to the right half of the lung to establish a lung injury model. Two and six months after irradiation, the right half of the rat lung tissue was removed, and the concentrations of TGF-β1, angiotensin II, and aldosterone were determined via enzyme-linked immunosorbent assay.Results Statistical differences were observed in the expression levels of angiotensin II and aldosterone between the non-irradiation and irradiation groups. Moreover, the expression level of the angiotensin II-aldosterone system increased with increasing doses, and the difference was still observed as time progressed.Conclusions Angiotensin II-aldosterone system has an important pathophysiological function in the progression of RILI.