RT Journal Article
SR Electronic
T1 Photodynamic Therapy for Gynecological Diseases and Breast Cancer
JF Cancer Biology & Medicine
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 9
OP 17
DO 10.3969/j.issn.2095-3941.2012.01.002
VO 9
IS 1
A1 Shishkova, Natashis
A1 Kuznetsova, Olga
A1 Berezov, Temirbolat
YR 2012
UL http://www.cancerbiomed.org/content/9/1/9.abstract
AB Photodynamic therapy (PDT) is a minimally invasive and promising new method in cancer treatment. Cytotoxic reactive oxygen species (ROS) are generated by the tissue-localized non-toxic sensitizer upon illumination and in the presence of oxygen. Thus, selective destruction of a targeted tumor may be achieved. Compared with traditional cancer treatment, PDI has advantages including higher selectivity and lower rate of toxicity. The high degree of selectivity of the proposed method was applied to cancer diagnosis using fluorescence. This article reviews previous studies done on PDT treatment and photodetection of cervical intraepithelial neoplasia, vulvar intraepithelial neoplasia, ovarian and breast cancer, and PDT application in treating non-cancer lesions. The article also highlights the clinical responses to PDT, and discusses the possibility of enhancing treatment efficacy by combination with immunotherapy and targeted therapy.