RT Journal Article
SR Electronic
T1 Meta-Analysis of the Association between Mir-196a-2 Polymorphism and Cancer Susceptibility
JF Cancer Biology & Medicine
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 63
OP 72
DO 10.3969/j.issn.2095-3941.2012.01.012
VO 9
IS 1
A1 Zhang, Huan
A1 Su, Yu-liang
A1 Yu, Herbert
A1 Qian, Bi-yun
YR 2012
UL http://www.cancerbiomed.org/content/9/1/63.abstract
AB Objective MicroRNA plays a vital role in gene expression, and microRNA dysregulation is involved in carcinogenesis. The miR-196a-2 polymorphism rs11614913 is reportedly associated with cancer susceptibility. This meta-analysis was performed to assess the overall association of miR-196a-2 with cancer risk.Methods A total of 27 independent case-control studies involving 10,435 cases and 12,075 controls were analyzed for the rs11614913 polymorphism.Results A significant association was found between rs11614913 polymorphism and cancer risk in four genetic models (CT vs. TT, OR=1.15, 95%CI=1.05–1.27; CC vs. TT, OR=1.23, 95%CI=1.08–1.39; Dominant model, OR=1.17, 95%CI=1.06–1.30; Additive model, OR=1.08, 95%CI=1.01–1.14). In the subgroup analysis of different tumor types, the C allele was associated with increased risk of lung, breast, and colorectal cancer, but not with liver, gastric, or esophageal cancer. In the subgroup analysis by ethnicity, a significantly increased risk of cancer was found among Asians in all genetic models, but no associations were found in the Caucasian subgroup.Conclusions The meta-analysis demonstrated that the miR-196a-2 polymorphism is associated with cancer susceptibility, especially lung cancer, colorectal cancer, and breast cancer among Asian populations.