RT Journal Article
SR Electronic
T1 Relationship between the Expression of VEGF, Flk-1 and Flt —1 Proteins and Clinicopathology in Hepatocellular Carcinoma
JF Chinese Journal of Clinical Oncology
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 412
OP 416
VO 1
IS 6
A1 Jihui Hao
A1 Huikai Li
A1 Yu Qin
A1 Qiang Li
A1 Dianchang Wang
A1 Xishan Hao
YR 2004
UL http://www.cancerbiomed.org/content/1/6/412.abstract
AB OBJECTIVE To study the relationship between the expression of VEGF, Flk-1 and Flt—1 proteins and clinical pathology in hepatocellular carcinoma.METHODS The expression of VEGF, Flk-1 and Flt—1 proteins in hepatocellular carcinomas from 60 patients was determined by immunohistochemistry (ABC method) and VEGF expression in relation to the clinicopathology evaluated.RESULTS The positive rates of VEGF, Flk-1 and Flt — 1 protein expression were 81.3%, 88.3%, 80.0% in tumor tissues, respectively, rates which were significantly higher than those in normal liver tissue (P<0.05). The expression of VEGF protein was correlated with the histologic grade and metastases of the tumors.CONCLUSION The results showed that, in hepatocellular carcinoma, a higher expression of VEGF protein was associated with a higher degree of malignancy and a greater tendency for metastases. VEGF, Flk-1 and Flt—1 play an important role in tumourgenesis.