PT  - JOURNAL ARTICLE
AU  - Jihui Hao
AU  - Huikai Li
AU  - Yu Qin
AU  - Qiang Li
AU  - Dianchang Wang
AU  - Xishan Hao
TI  - Relationship between the Expression of VEGF, Flk-1 and Flt —1 Proteins and Clinicopathology in Hepatocellular Carcinoma
DP  - 2004 Dec 01
TA  - Chinese Journal of Clinical Oncology
PG  - 412--416
VI  - 1
IP  - 6
4099  - http://www.cancerbiomed.org/content/1/6/412.short
4100  - http://www.cancerbiomed.org/content/1/6/412.full
SO  - Cancer Biol Med2004 Dec 01; 1
AB  - OBJECTIVE To study the relationship between the expression of VEGF, Flk-1 and Flt—1 proteins and clinical pathology in hepatocellular carcinoma.METHODS The expression of VEGF, Flk-1 and Flt—1 proteins in hepatocellular carcinomas from 60 patients was determined by immunohistochemistry (ABC method) and VEGF expression in relation to the clinicopathology evaluated.RESULTS The positive rates of VEGF, Flk-1 and Flt — 1 protein expression were 81.3%, 88.3%, 80.0% in tumor tissues, respectively, rates which were significantly higher than those in normal liver tissue (P<0.05). The expression of VEGF protein was correlated with the histologic grade and metastases of the tumors.CONCLUSION The results showed that, in hepatocellular carcinoma, a higher expression of VEGF protein was associated with a higher degree of malignancy and a greater tendency for metastases. VEGF, Flk-1 and Flt—1 play an important role in tumourgenesis.