<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hao, Jihui</style></author><author><style face="normal" font="default" size="100%">Li, Huikai</style></author><author><style face="normal" font="default" size="100%">Qin, Yu</style></author><author><style face="normal" font="default" size="100%">Li, Qiang</style></author><author><style face="normal" font="default" size="100%">Wang, Dianchang</style></author><author><style face="normal" font="default" size="100%">Hao, Xishan</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Relationship between the Expression of VEGF, Flk-1 and Flt —1 Proteins and Clinicopathology in Hepatocellular Carcinoma</style></title><secondary-title><style face="normal" font="default" size="100%">Chinese Journal of Clinical Oncology</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2004</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2004-12-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">412-416</style></pages><volume><style face="normal" font="default" size="100%">1</style></volume><issue><style face="normal" font="default" size="100%">6</style></issue><abstract><style  face="normal" font="default" size="100%">OBJECTIVE To study the relationship between the expression of VEGF, Flk-1 and Flt—1 proteins and clinical pathology in hepatocellular carcinoma.METHODS The expression of VEGF, Flk-1 and Flt—1 proteins in hepatocellular carcinomas from 60 patients was determined by immunohistochemistry (ABC method) and VEGF expression in relation to the clinicopathology evaluated.RESULTS The positive rates of VEGF, Flk-1 and Flt — 1 protein expression were 81.3%, 88.3%, 80.0% in tumor tissues, respectively, rates which were significantly higher than those in normal liver tissue (P&lt;0.05). The expression of VEGF protein was correlated with the histologic grade and metastases of the tumors.CONCLUSION The results showed that, in hepatocellular carcinoma, a higher expression of VEGF protein was associated with a higher degree of malignancy and a greater tendency for metastases. VEGF, Flk-1 and Flt—1 play an important role in tumourgenesis.</style></abstract></record></records></xml>