TY - JOUR T1 - An Open-Label Study of Pegylated Liposomal Doxorubicin, Vincristine, and Reduced-Dose Dexamethasone Combination Therapy in Newly Diagnosed Multiple Myeloma Patients in the Chinese Population JF - Clinical Oncology and Cancer Research JO - Cancer Biol Med SP - 394 LP - 400 DO - 10.1007/s11805-009-0394-2 VL - 6 IS - 6 AU - Yang Shen AU - Zhixiang Shen AU - Bin Jiang AU - Jian Hou AU - Rong Zhan AU - Lugui Qiu AU - Daobin Zhou AU - Jie Jin AU - Juan Li AU - Fanyi Meng AU - Ping Zou AU - Ting Liu AU - Jianyong Li AU - Chun Wang AU - Depei Wu AU - Jun Ma Y1 - 2009/12/01 UR - http://www.cancerbiomed.org/content/6/6/394.abstract N2 - OBJECTIVE Though doxorubicin is highly active in the treatment of multiple myeloma, its toxicity profile limits its therapeutic index. We performed this study to evaluate the efficacy and safety of pegylated liposomal doxorubicin (PLD, Caelyx®), vincristine, and reduced-dose dexamethasone combination therapy in newly diagnosed multiple myeloma (MM) patients in a Chinese population.METHODS This was an open-label, single-arm study in which newly diagnosed patients with MM received PLD 40 mg/m2 intravenously on Day 1, vincristine 1.4 mg/m2 intravenously (maximum 2 mg) on Day 1, and 40 mg of dexamethasone (intravenously or orally) from Day 1 to Day 4. Treatment was repeated every 28 days for at least 4 cycles.RESULTS In the intent-to-treat (ITT) analysis, the overall response rate was 68.29%, and the complete remission rate was 10.98%. The incidence of all adverse events was 46.34%. The most common non-hematologic toxicities were palmar-plantar erythrodysesthesia (13.4%) and stomatitis (6.1%).CONCLUSION PLD, vincristine, and a reduced-dose dexamethasone combination (DVd) is an effective and safe regimen in newly diagnosed MM patients in a Chinese population. ER -