PT  - JOURNAL ARTICLE
AU  - Hu, Guoqing
AU  - Fu, Qiang
AU  - Jin, Maolin
AU  - Li, Jie
AU  - Pan, Liangxi
AU  - Bai, Yuxian
AU  - Wang, Huaijin
AU  - Zhang, Jianwei
AU  - Yu, Ding
TI  - Clinical Research on Use of Oxaliplatin in Combination with HCPT, LV and 5FU in a Regimen for Advanced Gastric Cancer
DP  - 2004 Oct 01
TA  - Chinese Journal of Clinical Oncology
PG  - 336--341
VI  - 1
IP  - 5
4099  - http://www.cancerbiomed.org/content/1/5/336.short
4100  - http://www.cancerbiomed.org/content/1/5/336.full
SO  - Cancer Biol Med2004 Oct 01; 1
AB  - OBJECTIVE To observe the effects and adverse reactions of a OXA-HCPT LV/5FU 3 regimen for patients with advanced gastric cancer.METHODS OHLF 3 regimen: OXA 130 mg/m2iv d 1, HCPT 6 mg / m2, iv d 1~5, LV 200 mg/m2iv 2 h followed by a 5FU 400 mg/m2 iv bolus and 5FU 600 mg/m2 iv d 1-3, were given, every 21 days as 1 cycle. Assessment of the tumor was conducted after 3 cycles and the effective cases were confirmed after 4 weeks.RESULTS Among 39 patients, 36 were actually evaluable. Overall response rates (CR + PR) were 50%; the major adverse reactions were mild hematological toxicity, nausea and vomiting and peripheral nerve abnormalities.CONCLUSION The OHLF 3 regimen using OXA and HCPT Is effective and results in mild toxicity when used In combined chemotherapy for advanced gastric cancer.