RT Journal Article
SR Electronic
T1 Clinical Effects of Treatment for Lung Cancer with Double Points Cryoablation through Percutaneous Puncture Guided by Computed Tomography
JF Clinical Oncology and Cancer Research
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 322
OP 327
DO 10.1007/s11805-009-0322-5
VO 6
IS 5
A1 Zao Jiang
A1 Gaojun Teng
A1 Wen Fang
A1 Xiaoyi Gu
A1 Guozhao Li
YR 2009
UL http://www.cancerbiomed.org/content/6/5/322.abstract
AB OBJECTIVE To investigate the clinical effects of the application of double points cryoablation through percutaneous puncture for advanced lung cancer patients.METHODS Forty-one patients diagnosed with stage III-IV pulmonary carcinoma were selected for the study. The patients were found to have from 1 to 3 foci of carcinoma, and in each case the disease was limited to one lung. The study patients were divided randomly into 3 groups. There were 16 cases receiving routine chemotherapy and radiotherapy in group I, 13 cases treated with cryoablation at a single point in group II, and 12 cases treated with cryoablation at 2 points simultaneously in group III. The patients in the 2 cryoablation groups also received the same treatment as the patients did in group I. The clinical effects were evaluated within 6 months aft er treatment, and the survival rate was followed-up for 3 years.RESULTS The clinical effects were improved significantly aft er treatment in group II and in group III compared with those in group I (P < 0.05), including an enhanced regressive rate of 21%, postponed tumor progression of 50.58% and a clinical benefit rate of 92%. The effective rate of regression in group III was higher than that in group II, 43.59% (P < 0.05), and the 3-year survival rate was 37.25%. Significant differences in side effects were not found between the 2 cryoablation groups.CONCLUSION Cryosurgery ablation at 2 points, simultaneously, and directed at 1 foci might improve the effects of treatment and the prognosis of lung cancer patients, when used in combination with routine treatment.