PT  - JOURNAL ARTICLE
AU  - Bin Zhang
AU  - Yue Cai
AU  - Qi Zhang
AU  - Ziwei Ying
AU  - Shuling Jiang
AU  - Hong Xu
AU  - Yongxue Zheng
AU  - Daqing Jiang
TI  - Short–term Intensive Neoadjuvant Chemotherapy Improving 10–year Survival for Patients with Stage II and Operable Stage III Breast Cancer
DP  - 2004 Feb 01
TA  - Chinese Journal of Clinical Oncology
PG  - 42--46
VI  - 1
IP  - 1
4099  - http://www.cancerbiomed.org/content/1/1/42.short
4100  - http://www.cancerbiomed.org/content/1/1/42.full
SO  - Cancer Biol Med2004 Feb 01; 1
AB  - OBJECTIVE To evaluate the 10–year curative effects of short–term intensive neoadjuvant chemotherapy for operable breast cancer.METHODS A total of 510 patients with stagell and operable stagelll breast cancer were divided into group A (preoperative neoadjuvant chemotherapy 251 cases) and group B (postoperative adjuvant chemotherapy 259 cases). The patients in group A received short–term and intensive neoadjuvant chemotherapy for 4 weeks followed by modified radical mastectomy two weeks after the chemotherapy. The postoperative adjuvant chemotherapy began within two weeks after surgery. The same chemotherapeutic regimen was used for both groups.RESULTS For stage III in group A the 5–year overall survival rate (OS) and disease–free survival rate (DFS) were 59.2% and 54.9% respectively which were higher than those in group B (28.3% and 20.8% respectively, P<0.05). The 10–year OS and DFS were 78.1% and 73.5% respectively for stage II in group A which were higher than those in group B (68.4% and 60.7%, P< 0.05). The 10–year OS and DFS were 42.3% and 40.4% respectively for stage III in group A which were higher than those in group B (20.4% and 18.4% respectively, P<0.05).CONCLUSION The results showed that intensive neoadjuvant chemotherapy can improve the 10–year survival for patients with stage II and operable stage III breast cancer.