PT  - JOURNAL ARTICLE
AU  - Dongbing Zhao
AU  - Yongkai Wu
AU  - Yi Shan
AU  - Chengfeng Wang
AU  - Ping Zhao
TI  - Prognostic Factors of Ampulla of Vater Carcinoma after Radical Surgery
AID  - 10.1007/s11805-009-0085-z
DP  - 2009 Apr 01
TA  - Clinical Oncology and Cancer Research
PG  - 85--89
VI  - 6
IP  - 2
4099  - http://www.cancerbiomed.org/content/6/2/85.short
4100  - http://www.cancerbiomed.org/content/6/2/85.full
SO  - Cancer Biol Med2009 Apr 01; 6
AB  - OBJECTIVE Ampullary carcinoma is a rare disease with better prognosis than other periampullary neoplasms. This study investigated the association between clinicopathologic factors and prognosis after radical resection of ampulla of Vater carcinoma.METHODS Clinical data from 105 patients who underwent radical pancreaticoduodenectomy from January 1990 to December 2005 were retrospectively analyzed by the Kaplan-Meier method, log-rank test, and the Cox proportional hazard model.RESULTS The in-hospital mortality rate was 8.6%, the lymph node metastasis rate was 37.1%, and the five-year survival rate was 42.8%. Pancreatic involvement (P = 0.027), tumor diameter (P = 0.008), T stage (P = 0.003), TNM stage (P < 0.001), and number of metastatic lymph nodes (P < 0.001) were associated with prognosis when the univariate analysis was used. Multivariate analysis showed that the number of lymph node metastases (P < 0.001; OR: 1.923; CI: 1.367-2.705) and tumor diameter (P = 0.03; OR: 1.432; CI: 1.035-1.981) were the independent prognostic factors.CONCLUSION The number of metastatic lymph nodes and tumor diameter are important pathologic factors predicting prognosis of ampulla of Vater carcinoma after radical resection, and lymph node dissection during the radical surgery effectively improves the survival rate.