PT  - JOURNAL ARTICLE
AU  - Chongyang Wu
AU  - Liansheng Zhang
AU  - Ye Chai
AU  - Feixue Song
AU  - Pengyun Zeng
AU  - Lijuan Li
AU  - Lingling Yue
AU  - Bin Xiong
TI  - The Influence of IFN-α on Blood Plasmacytoid Dendritic Cell in Chronic Myeloid Leukaemia
AID  - 10.1007/s11805-009-0113-z
DP  - 2009 Apr 01
TA  - Clinical Oncology and Cancer Research
PG  - 113--116
VI  - 6
IP  - 2
4099  - http://www.cancerbiomed.org/content/6/2/113.short
4100  - http://www.cancerbiomed.org/content/6/2/113.full
SO  - Cancer Biol Med2009 Apr 01; 6
AB  - OBJECTIVE To study the mechanism of IFN on CML.METHODS Samples of 15 CML patients and 10 healthy controls were studied. The flow cytometry was performed to identify circulating pDCs. The concentration of IFN-α in serum and that in the supernatant of peripheral blood mononuclear cells (PBMCs) cultured after stimulation with CpG ODN2216 were examined both in CML patients and in the healthy controlsRESULTS There was significant reduction in the number of circulating pDCs, serum concentration of IFN-α and the capacity of IFN-α producing PBMCs in CML patients compared with those in healthy control individuals (P < 0.001). After the active treatment with IFN-α and hydroxyurea, the quantity and function of pDCs were increased in stabilized patients, especially the function of pDCs in 2 patients achieving major cytogenetic response (MCR). The proportion and function of pDCs and the serum levels of IFN were inversely correlated with both WBC and age of the patients with CML, and positively correlated with the state of the illness.CONCLUSION CML patients had a reduced number and dysfunction of circulating pDCs. The active treatment with IFN in CML patients may be related to the restoration of pDCs.