RT Journal Article
SR Electronic
T1 The Significance of Minimally Invasive Core Needle Biopsy and Immunohistochemistry Analysis in 235 Cases with Breast Lesions
JF Clinical Oncology and Cancer Research
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 36
OP 41
DO 10.1007/s11805-009-0036-8
VO 6
IS 1
A1 Yun Niu
A1 Tieju Liu
A1 Xuchen Cao
A1 Xiumin Ding
A1 Li Wei
A1 Yuxia Gao
A1 Jun Liu
YR 2009
UL http://www.cancerbiomed.org/content/6/1/36.abstract
AB OBJECTIVE To evaluate core needle biopsy (CNB) as a minimally invasive method to examine breast lesions and discuss the clinical significance of subsequent immunohistochemistry (IHC) analysis.METHODS The clinical data and pathological results of 235 patients with breast lesions, who received CNB before surgery, were analyzed and compared. Based on the results of CNB done before surgery, 87 out of 204 patients diagnosed as invasive carcinoma were subjected to immunodetection for p53, c-erbB-2, ER and PR. The morphological change of cancer tissues in response to chemotherapy was also evaluated.RESULTS In total of 235 cases receiving CNB examination, 204 were diagnosed as invasive carcinoma, reaching a 100% consistent rate with the surgical diagnosis. Sixty percent of the cases diagnosed as non-invasive carcinoma by CNB was identified to have the presence of invading elements in surgical specimens, and similarly, 50% of the cases diagnosed as atypical ductal hyperplasia by CNB was confirmed to be carcinoma by the subsequent result of excision biopsy. There was no significant difference between the CNB biopsy and regular surgical samples in positive rate of immunohistochemistry analysis (p53, c-erbB-2, ER and PR; P > 0.05). However, there was significant difference in the expression rate of p53 and c-erbB-2 between the cases with and without morphological change in response to chemotherapy (P < 0.05). In most cases with p53 and c-erbB-2 positive, there was no obvious morphological change after chemotherapy.CONCLUSION CNB is a cost-effective diagnostic method with minimal invasion for breast lesions, although it still has some limitations. Immunodetection on CNB tissue is expected to have great significance in clinical applications.