PT  - JOURNAL ARTICLE
AU  - Fang, Tong
AU  - Liu, Bo
AU  - Gao, Hong
TI  - Study on Fractionated Total Body Irradiation before Hematopoietic Stem Cell Transplantation
AID  - 10.1007/s11805-009-0047-5
DP  - 2009 Feb 01
TA  - Clinical Oncology and Cancer Research
PG  - 47--50
VI  - 6
IP  - 1
4099  - http://www.cancerbiomed.org/content/6/1/47.short
4100  - http://www.cancerbiomed.org/content/6/1/47.full
SO  - Cancer Biol Med2009 Feb 01; 6
AB  - OBJECTIVE To observe the dose and the complications from total body irradiation before hematopoietic stem cell transplantation.METHODS This study involved 312 patients with total body irradiation before hematopoietic stem cell transplantation. They were entered into the treated research from May 1999 to October 2005. All patients had received the irradiation from 60Co of an absorbed dose rate of (5.2 ± 1.13) cGy/min. The total dose of TBI was 7~12 Gy, 1 f/d × 2 d. A high-dose rate group (≥ 10 Gy) included 139 cases and a low-dose rate group (< 10 Gy) included 173 cases.RESULTS The probability of acute gastrointestinal reactions in the high-dose rate group was more compared with that in the low-dose rate group. The differences for other reactions, such as hematopoietic reconstitution and graft survival rate, between the two groups were insignificant.CONCLUSION Using fractional total body irradiation at a dose rate of 5 cGy/min, with a total dose of 7~12 Gy, 1 f/d × 2 d, with the lung receiving under 7.5 Gy is a safe and effective pretreatment for hematopoietic stem cell transplantation.