RT Journal Article
SR Electronic
T1 Emerging data supporting stromal cell therapeutic potential in cancer: reprogramming stromal cells of the tumor microenvironment for anti-cancer effects
JF Cancer Biology and Medicine
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 828
OP 841
DO 10.20892/j.issn.2095-3941.2020.0133
VO 17
IS 4
A1 Armel Hervé Nwabo Kamdje
A1 Paul Faustin Seke Etet
A1 Richard Tagne Simo
A1 Lorella Vecchio
A1 Kiven Erique Lukong
A1 Mauro Krampera
YR 2020
UL http://www.cancerbiomed.org/content/17/4/828.abstract
AB After more than a decade of controversy on the role of stromal cells in the tumor microenvironment, the emerging data shed light on pro-tumorigenic and potential anti-cancer factors, as well as on the roots of the discrepancies. We discuss the pro-tumorigenic effects of stromal cells, considering the effects of tumor drivers like hypoxia and tumor stiffness on these cells, as well as stromal cell-mediated adiposity and immunosuppression in the tumor microenvironment, and cancer initiating cells’ cellular senescence and adaptive metabolism. We summarize the emerging data supporting stromal cell therapeutic potential in cancer, discuss the possibility to reprogram stromal cells of the tumor microenvironment for anti-cancer effects, and explore some causes of discrepancies on the roles of stromal cells in cancer in the available literature.